Table2_Associations between MTHFR gene polymorphisms (C677T and A1298C) and genetic susceptibility to prostate cancer: a systematic review and meta-analysis.DOCX

Background: The association between MTHFR gene polymorphisms (C677T and A1298C) and prostate cancer risk remains controversial.Methods: Two independent researchers searched the PubMed, Embase, Cochrane and Web of Science databases for all papers published up to 12/19/2023 and used various genetic models to evaluate the relationship between MTHFR polymorphisms and prostate cancer risk.Results: The meta-analysis included 26 case‒control studies with a total of 12,455 cases and 13,900 controls with the C677T polymorphism and 6,396 cases and 8,913 controls with the A1298C polymorphism. Overall, no significant association was found between the MTHFR gene polymorphisms and prostate cancer risk. However, the C677T polymorphism was associated with reduced prostate cancer risk in the Asian population (T allele vs. C allele: OR = 0.759, 95% CI 0.669–0.861, p Conclusion: The meta-analysis suggested that MTHFR gene polymorphisms (C677T and A1298C) may have different effects on prostate cancer risk in specific populations.</p

Table1_Associations between MTHFR gene polymorphisms (C677T and A1298C) and genetic susceptibility to prostate cancer: a systematic review and meta-analysis.DOCX

Background: The association between MTHFR gene polymorphisms (C677T and A1298C) and prostate cancer risk remains controversial.Methods: Two independent researchers searched the PubMed, Embase, Cochrane and Web of Science databases for all papers published up to 12/19/2023 and used various genetic models to evaluate the relationship between MTHFR polymorphisms and prostate cancer risk.Results: The meta-analysis included 26 case‒control studies with a total of 12,455 cases and 13,900 controls with the C677T polymorphism and 6,396 cases and 8,913 controls with the A1298C polymorphism. Overall, no significant association was found between the MTHFR gene polymorphisms and prostate cancer risk. However, the C677T polymorphism was associated with reduced prostate cancer risk in the Asian population (T allele vs. C allele: OR = 0.759, 95% CI 0.669–0.861, p Conclusion: The meta-analysis suggested that MTHFR gene polymorphisms (C677T and A1298C) may have different effects on prostate cancer risk in specific populations.</p

Table3_Associations between MTHFR gene polymorphisms (C677T and A1298C) and genetic susceptibility to prostate cancer: a systematic review and meta-analysis.DOCX

Background: The association between MTHFR gene polymorphisms (C677T and A1298C) and prostate cancer risk remains controversial.Methods: Two independent researchers searched the PubMed, Embase, Cochrane and Web of Science databases for all papers published up to 12/19/2023 and used various genetic models to evaluate the relationship between MTHFR polymorphisms and prostate cancer risk.Results: The meta-analysis included 26 case‒control studies with a total of 12,455 cases and 13,900 controls with the C677T polymorphism and 6,396 cases and 8,913 controls with the A1298C polymorphism. Overall, no significant association was found between the MTHFR gene polymorphisms and prostate cancer risk. However, the C677T polymorphism was associated with reduced prostate cancer risk in the Asian population (T allele vs. C allele: OR = 0.759, 95% CI 0.669–0.861, p Conclusion: The meta-analysis suggested that MTHFR gene polymorphisms (C677T and A1298C) may have different effects on prostate cancer risk in specific populations.</p

Impacts of Siberian Biomass Burning on Organic Aerosols over the North Pacific Ocean and the Arctic: Primary and Secondary Organic Tracers

During the 2003 Chinese Arctic Research Expedition (CHINARE2003) from the Bohai Sea to the high Arctic (37°N–80°N), filter-based particle samples were collected and analyzed for tracers of primary and secondary organic aerosols (SOA) as well as water-soluble organic carbon (WSOC). Biomass burning (BB) tracer levoglucosan had comparatively much higher summertime average levels (476 ± 367pg/m³) during our cruise due to the influence of intense forest fires then in Siberia. On the basis of 5-day back trajectories, samples with air masses passing through Siberia had organic tracers 1.3–4.4 times of those with air masses transporting only over the oceans, suggesting substantial contribution of continental emissions to organic aerosols in the marine atmosphere. SOA tracers from anthropogenic aromatics were negligible or not detected, while those from biogenic terpenenoids were ubiquitously observed with the sum of SOA tracers from isoprene (623 ± 414pg/m³) 1 order of magnitude higher than that from monoterpenes (63 ± 49 pg/m³). 2-Methylglyceric acid as a product of isoprene oxidation under high-NO_<i>x</i> conditions was dominant among SOA tracers, implying that these BSOA tracers were not formed over the oceans but mainly transported from the adjacent Siberia where a high-NO_<i>x</i> environment could be induced by intense forest fires. The carbon fractions shared by biogenic SOA tracers and levoglucosan in WSOC in our ocean samples were 1–2 orders of magnitude lower than those previously reported in continental samples, BB emissions or chamber simulation samples, largely due to the chemical evolution of organic tracers during transport. As a result of the much faster decline in levels of organic tracers than that of WSOC during transport, the trace-based approach, which could well reconstruct WSOC using biogenic SOA and BB tracers for continental samples, only explained ∼4% of measured WSOC during our expedition if the same tracer-WSOC or tracer-SOC relationships were applied

Modern and Fossil Contributions to Polycyclic Aromatic Hydrocarbons in PM_2.5 from North Birmingham, Alabama in the Southeastern U.S.

Analyzing the radiocarbon (¹⁴C) content of polycyclic aromatic hydrocarbons (PAHs) in atmospheric particulate matter can provide estimates on the source contributions from biomass burning versus fossil fuel. The relative importance of these two sources to ambient PAHs varies considerably across regions and even countries, and hence there is a pressing need to apportion these sources. In this study, we advanced the radiocarbon analysis from bulk carbon to compound class specific radiocarbon analysis (CCSRA) to determine Δ¹⁴C and δ¹³C values of PAHs in PM_2.5 samples for investigating biomass burning and fossil fuel source contributions to PAHs from one of the Southeastern Aerosol Research and Characterization (SEARCH) sites in North Birmingham (BHM), Alabama during winter (December 2004-February 2005) and summer (June-August 2005) by accelerator mass spectrometry. To compare our ambient samples to known sources, we collected and analyzed fenceline samples from the vicinity of a coke plant in BHM. As expected, PAHs from the coke plant fenceline samples had very low radiocarbon levels. Its Δ¹⁴C varied from −990 to −970‰, indicating that 97 to 99% were of fossil source. PAHs in the ambient PM_2.5 had Δ¹⁴C from −968 to −911 ‰, indicating that 92–97% of PAHs were from fossil fuel combustion. These levels indicated the dominance of fossil sources of ambient PAHs. The radiocarbon level of ambient PAHs was higher in winter than in summer. Winter samples exhibited depleted δ¹³C value and enriched Δ¹⁴C value because of the increased contribution of PAHs from biomass burning source. However, biomass burning contributed more to heavier PAHs (modern source accounting for 6–8%) than lighter ones with a modern contribution of 3%

Antibodies against HLA/MICA antigens in pre- and post-transplant serum samples.

<p>IgG antibodies against HLA class I and II antigens and MICA antigens were measured by single antigen Luminex beads arrays. MFI values represent the quantitation of alloantibodies detected. (A) The donor’s and recipient’s HLA antigen types and the positive reacted HLA antigens (others) with test serum samples are labeled as grouped.The MFI values of antibodies detected from patient serum before (gray bars) and after the first transplant (solid bar) are given. (B) Anti-MICA antibodies were detected using 11 common MICA antigens. MICA001, MICA002, MICA007, MICA012, MICA017, and MICA018, all from the MICA-G1 antigen group were present in pre- and post-first transplant patient sera; other antigens tested were negative. DSA to the antigen produced by MICA*018 allele is indicated with an arrow. C1q-PE, rather than goat anti human IgG conjugated with PE, was used to demonstrate the complement fix (C1q, white bars).</p

HLA/MICA typing results.

<p>HLA/MICA typing results.</p

MICA expressed on HUVEC cell surfaces is the target for anti-MICA antibodies.

<p>(A) HUVECs were freshly isolated from five umbilical cord samples. Cells were stained with mAb W6/32 for HLA class I antigens (solid profile), 6B3 for MICA antigens (open profile; dark line) and normal mouse IgG as control (open profile; light line). (B). HUVECs were incubated with normal human serum (NHS), pooled PRA+ sera (POS), or patient serum (after first transplant, with platelet absorption). Cytotoxicity is reported as percent lysis.</p

C4d deposition in the walls of glomerular capillaries of allograft.

<p>Immunofluorescent microscopic magnification×400.</p

Additional file 1: of Polymorphism rs189037CÂ >Â T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study

The raw data used in this paper. (XLS 50 kb